Identifying the molecular determinants of Schistosoma mansoni reproduction & longevity

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Home > Publications > Biology

2015-present

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2017

 

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases
Scholte, L. L. S., Mourao, M. M., Pais, F. S., Melesina, J., Robaa, D., Volpini, A. C., Sippl, W., Pierce, R. J., Oliveira, G., and Nahum, L. A. ,2017, Infect Genet Evol., 17, 30162-4.

DOI:10.1016/j.meegid.2017.05.011

 

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
Chua, M. J., Arnold, M. S., Xu, W., Lancelot, J., Lamotte, S., Spath, G. F., Prina, E., Pierce, R. J., Fairlie, D. P., Skinner-Adams, T. S., and Andrews, K. T., 2017 , Int J Parasitol Drugs Drug Resist 7, 42-50.

DOI:10.1016/j.ijpddr.2016.12.005

 

Evidence for Integrin - Venus Kinase Receptor 1 Alliance in the Ovary of Schistosoma mansoni Females Controlling Cell Survival
Gelmedin, V., Morel, M., Hahnel, S., Cailliau, K., Dissous, C., Grevelding, C. G., 2017, PLoS Pathog, 13,

DOI: 10.1371/journal.ppat.1006147

 

First characterization of SmOPG1, a novel protein involved in gonad-associated processes in Schistosoma mansoni
Hahnel, S., Parker-Manuel, R., Dissous, C., Cailliau, K., Grevelding, C. G.,2017, Mol Biochem Parasitol, 213, 22-25.

DOI:10.1016/j.molbiopara.2017.01.007

 

 

2016

 

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni
Marek, M., Shaik, T. B., Jung, M., Sippl, W., Pierce, R. J., and Romier,2016, C. Biol Aujourdhui 210, 311-320.

DOI:10.1051/jbio/2017001

 

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni
Marek, M., Shaik, T. B., Duclaud, S., Pierce, R. J., and Romier, C. , 2016, Methods Mol Biol 1436, 109-18.

DOI:10.1007/978-1-4939-3667-0_8

 

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis
Heimburg, T., Chakrabarti, A., Lancelot, J., Marek, M., Melesina, J., Hauser, A. T., Shaik, T. B., Duclaud, S., Robaa, D., Erdmann, F., Schmidt, M., Romier, C., Pierce, R. J., Jung, M., and Sippl, W. ,2016, J Med Chem 59, 2423-35.

DOI:10.1021/acs.jmedchem.5b01478

 

Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins
Cabezas-Cruz, A., Tonk, M., Bouchut, A., Pierrot, C., Pierce, R. J., Kotsyfakis, M., Rahnamaeian, M., Vilcinskas, A., Khalife, J., and Valdes, J. J. , 2016, Front Microbiol, 7, 1682.
DOI:10.3389/fmicb.2016.01682

 

Caspase Cleavages of the Lymphocyte-oriented Kinase Prevent Ezrin, Radixin, and Moesin Phosphorylation during Apoptosis
Leroy, C., Belkina, N. V., Long, T., Deruy, E., Dissous, C., Shaw, S., Tulasne, D., 2016, J Biol Chem, 291, 10148-61.

DOI:10.1074/jbc.M116.721365

 

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Long, T., Neitz, R., J., Beasley, R., Kalyanaraman, C., Suzuki, B. M., Jacobson, M. P., Dissous, C., McKerrow, J. H., Drewry, D. H., Zuercher, W. J., Singh, R., Caffrey, C. R., 2016, PLoS Negl Trop Dis, 10, e0004356.

DOI:10.1371/journal.pntd.0004356

 

SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways
Morel, M., Vanderstraete, M., Cailliau, K., Hahnel, S., Grevelding, C. G., Dissous, C., 2016, PLoS One, 11, e0163283.

DOI:10.1371/journal.pone.0163283

 

 

2015

 

Fluorescence-based screening assays for the NAD(+)-dependent histone deacetylase smSirt2 from Schistosoma mansoni
Schiedel, M., Marek, M., Lancelot, J., Karaman, B., Almlof, I., Schultz, J., Sippl, W., Pierce, R. J., Romier, C., and Jung, M. ,2015, J Biomol Screen 20, 112-21.

DOI:10.1177/1087057114555307

 

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors
Melesina, J., Robaa, D., Pierce, R. J., Romier, C., and Sippl, W. ,2015, J Mol Graph Model 62, 342-61.

DOI:10.1016/j.jmgm.2015.10.006

 

Schistosome sirtuins as drug targets
Lancelot, J., Cabezas-Cruz, A., Caby, S., Marek, M., Schultz, J., Romier, C., Sippl, W., Jung, M., and Pierce, R. J. ,2015, Future Med Chem 7, 765-82.

DOI:10.4155/fmc.15.24

 

HDAC8: a multifaceted target for therapeutic interventions
Chakrabarti, A., Oehme, I., Witt, O., Oliveira, G., Sippl, W., Romier, C., Pierce, R. J., and Jung, M. , 2015, Trends Pharmacol Sci 36, 481-92.

DOI:10.1016/j.tips.2015.04.013

 

Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni
Cabezas-Cruz, A., Valdes, J. J., Lancelot, J., and Pierce, R. J. ,2015, BMC Genomics 16, 980.

DOI:10.1186/s12864-015-2144-6

 

Venus Kinase Receptors at the Crossroads of Insulin Signaling: Their Role in Reproduction for Helminths and Insects
Dissous, C., 2015, Front Endocrinol, 6, 118-

DOI: 10.3389/fendo.2015.00118