Identifying the molecular determinants of Schistosoma mansoni reproduction & longevity

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Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Laurent Raibaut, Marine Cargoët, Nathalie Ollivier, Yun Min Chang, Hervé Drobecq, Emmanuelle Boll, Rémi Desmet, Jean-Christophe M. Monbaliu and Oleg Melnyk, Chem. Sci. , 2016, 7, 2657-2665.
DOI: 10.1039/C5SC03459K


Kinetically controlled chemoselective cyclization simplifies the access to cyclic and branched peptides
Boll, E., Drobecq, H., Lissy, E., Cantrelle, F.-X., Melnyk, O. Org. Lett. 2016, 18, 3842-3845.
DOI: 10.1021/acs.orglett.6b01847.


Cysteine 52 is the Achilles’ heel of SUMO-1
Drobecq, H. ; Boll, E. ; Sénéchal, M. ; Desmet, R. ; Saliou, J. M. ; Lacapère, J.-J. ; Mougel, A. ; Vicogne, V. ; Melnyk, O. Bioconjugate Chem. 2016, 27 1540–1546.
DOI: 10.1021/acs.bioconjchem.6b00211


Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Pira, S. L., El Mahdi, O., Raibaut, L., Drobecq, H., Dheur, J., Boll, E., and Melnyk, O. Org. Biomol. Chem. 2016, 14, 7211-7216.
DOI : 10.1039/C6OB01079B


Total chemical synthesis of SUMO proteins
Melnyk, O.; Vicogne, J. Tetrahedron Letters 2016 , 57, 4319-4324.
DOI: 10.1016/j.tetlet.2016.08.035




Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds
Raibaut, L.; Drobecq, H.; Melnyk, O. Org. Lett. 2015, 17, 3636–3639.
DOI : 10.1021/acs.orglett.5b01817


Synthesis of unprotected linear or cyclic O-acyl isopeptides in water using bis(2-sulfanylethyl)amido peptide ligation
Desmet, R. ; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O. Org. Lett. 2015, 17, 3354-3357.
DOI: 10.1021/acs.orglett.5b01614


One-pot chemical synthesis of small ubiquitin-like modifier (SUMO) protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates
Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J. & Melnyk, O. Nat. Protocols
2015, 10, 269-292.

DOI: 10.1038/nprot.2015.013


Solid phase protein synthesis
Raibaut, L., El Madhi, O., Melnyk, O. Topics Curr. Chem. 2015, 363, 103-154.
DOI: 10.1007/128_2014_609


Access to large cyclic peptides by a one-pot two peptide segments ligation/cyclization process
Boll, E. ; Ebran, J.-P.; Drobecq, H.; El-Mahdi, O.; Raibaut, L.; Ollivier, N.; Melnyk, O. Org. Lett. 2015, 17, 130-133.
DOI: 10.1021/ol503359w


Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist
Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, J.
Chem. Sci., 2015,6, 2110-2121.

DOI: 10.1039/C4SC03856H