Identifying the molecular determinants of Schistosoma mansoni reproduction & longevity

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Home > Publications > Chemical Biology

2015-present

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Some articles can be downloaded from this website

You can find also there some proceedings and posters from CBC team.

 

2016

 

Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Laurent Raibaut, Marine Cargoët, Nathalie Ollivier, Yun Min Chang, Hervé Drobecq, Emmanuelle Boll, Rémi Desmet, Jean-Christophe M. Monbaliu and Oleg Melnyk, Chem. Sci. , 2016, 7, 2657-2665.
DOI: 10.1039/C5SC03459K

 

Kinetically controlled chemoselective cyclization simplifies the access to cyclic and branched peptides
Boll, E., Drobecq, H., Lissy, E., Cantrelle, F.-X., Melnyk, O. Org. Lett. 2016, 18, 3842-3845.
DOI: 10.1021/acs.orglett.6b01847.

 

Cysteine 52 is the Achilles’ heel of SUMO-1
Drobecq, H. ; Boll, E. ; Sénéchal, M. ; Desmet, R. ; Saliou, J. M. ; Lacapère, J.-J. ; Mougel, A. ; Vicogne, V. ; Melnyk, O. Bioconjugate Chem. 2016, 27 1540–1546.
DOI: 10.1021/acs.bioconjchem.6b00211

 

Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Pira, S. L., El Mahdi, O., Raibaut, L., Drobecq, H., Dheur, J., Boll, E., and Melnyk, O. Org. Biomol. Chem. 2016, 14, 7211-7216.
DOI : 10.1039/C6OB01079B

 

Total chemical synthesis of SUMO proteins
Melnyk, O.; Vicogne, J. Tetrahedron Letters 2016 , 57, 4319-4324.
DOI: 10.1016/j.tetlet.2016.08.035

 

2015

 

Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds
Raibaut, L.; Drobecq, H.; Melnyk, O. Org. Lett. 2015, 17, 3636–3639.
DOI : 10.1021/acs.orglett.5b01817

 

Synthesis of unprotected linear or cyclic O-acyl isopeptides in water using bis(2-sulfanylethyl)amido peptide ligation
Desmet, R. ; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O. Org. Lett. 2015, 17, 3354-3357.
DOI: 10.1021/acs.orglett.5b01614

 

One-pot chemical synthesis of small ubiquitin-like modifier (SUMO) protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates
Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J. & Melnyk, O. Nat. Protocols
2015, 10, 269-292.

DOI: 10.1038/nprot.2015.013

 

Solid phase protein synthesis
Raibaut, L., El Madhi, O., Melnyk, O. Topics Curr. Chem. 2015, 363, 103-154.
DOI: 10.1007/128_2014_609

 

Access to large cyclic peptides by a one-pot two peptide segments ligation/cyclization process
Boll, E. ; Ebran, J.-P.; Drobecq, H.; El-Mahdi, O.; Raibaut, L.; Ollivier, N.; Melnyk, O. Org. Lett. 2015, 17, 130-133.
DOI: 10.1021/ol503359w

 

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist
Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, J.
Chem. Sci., 2015,6, 2110-2121.

DOI: 10.1039/C4SC03856H