Jérôme Vicogne


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Par en May 2017

Jérôme VICOGNE, researcher at CNRS, is the co-discoverer of the VKR family in S. mansoni. He spent most of his career on the structural and functional characterization of RTKs and their signaling pathways in invertebrates and human. He is leading the Biology-Chemistry interface in the CBF team together with O. Melnyk (Chemical Biology of Flatworms, UMR CNRS 9017 U1019, University of Lille, Pasteur Institute of Lille).

Jérôme VICOGNE, PhD, HDR
DOB: August 28th, 1977
Nationality: French

Chargé de Recherche (CRCN) CNRS
UMR9017 CNRS – U1019 INSERM, Center for Immunity and Infection of Lille, Institut Pasteur de Lille
1, rue du Pr Calmette, 59021 Lille - France

Contact:
email: jerome.vicogne@ibl.cnrs.fr
phone : +33 3 20 87 12 49

Educational Background:

  • 2012 HDR (Habilitation à la Direction de Recherches), University Lille 1, France.
  • 2003 PhD, Molecular Biology, Biochemistry and Parasitology, University Lille 2, France.
  • 1999 Master Research, Molecular Biology and Immunology, University Lille 1, France.
  • 1998 M. Sc, Molecular Biology and Genetics, University Lille 1, France.

Professional History:

  • Since 2013 CNRS Senior Reseacher (CRCN), CBF team S. mansoni Group Leader
  • 2009-2013 CNRS Researcher (CR2, HDR)
  • 2008-2009 Institut de Biologie de Lille, France, Young Researcher Scholarship
  • 2006-2008 Stony Brook University of New York, USA, Research Assistant
  • 2003-2006 Stony Brook University of New York, USA, Post Doctoral Scholarship

Research Interests:

  • Host-parasite relationship in Schistosoma mansoni model.
  • Receptor Tyrosine Kinase (RTK) functional and structural analysis.
  • Ligand-Receptor interactions (ALPHAScreen®, HTRF®, Epic Label-free® and SPR).
  • Transmembrane protein synthesis and purification strategies.
  • Recombinant, chemical and hybrid protein synthesis.
  • Design of micro and nanosystems for biodetection (Lab on chips).

Scientific & Technological Production – Contractual Activities
41 articles in peer-reviewed international journals, 25 communications in international conferences, 15 scientific seminars, 6 granted academic research projects, 3 book chapters, 2 patents.

List of peer-reviewed articles of the 5 last years
Leippe P, Broichhagen J, Cailliau K, Mougel A, Morel M, Dissous C, Trauner D, Vicogne J*.
Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors.
Angew Chem Int Ed Engl. 2019 Dec 23.

Bouchenna J, Sénéchal M, Drobecq H, Vicogne J*, Melnyk O.
Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations.
Bioconjug Chem. 2019 Nov 20;30(11):2967-2973.

Bouchenna J, Sénéchal M, Drobecq H, Stankovic-Valentin N, Vicogne J*, Melnyk O.
The Role of the Conserved SUMO-2/3 Cysteine Residue on Domain Structure Investigated Using Protein Chemical Synthesis.
Bioconjug Chem. 2019 Oct 16;30(10):2684-2696..

Mekki MS, Mougel A, Vinchent A, Paquet C, Copin MC, Leroy C, Kherrouche Z, Bonte JP, Melnyk O, Vicogne J*, Tulasne D.
Hypoxia leads to decreased autophosphorylation of the MET receptor and promotes its resistance to tyrosine kinase inhibitors.
Oncotarget. 2018; 9:27039-27058

Ollivier N, Desmet R, Drobecq H, Blanpain A, Boll E, Leclercq B, Mougel A, Vicogne J, Melnyk O.
A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins
Chem Sci. 2017, 6, 2110-21

Copin MC, Lesaffre M, Berbon M, Doublet L, Leroy C, Tresch E, Porte H, Vicogne J, Cortot A. B, Dansin E, Tulasne D.
High-MET status in non-small cell lung tumors correlates with receptor phosphorylation but not with the serum level of soluble form.
Lung Cancer. 2016 Nov; 101, 59-67

Melnyk O, Vicogne J.
Total Chemical synthesis of SUMO proteins.
Tetrahedron Letters. 2016 Sep; 57 (39): 4319-24

Drobecq H, Boll E, Sénéchal M, Desmet R, Saliou JM, Lacapère JJ, Mougel A, Vicogne J*, Melnyk O.
A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide-Protein Conjugates.
Bioconjug Chem. 2016 Jun 15;27(6):1540-6.

Simonneau C, Leclercq B, Mougel A, Adriaenssens E, Paquet C, Raibaut L, Ollivier N, Drobecq H, Marcoux J, Cianferani S, Tulasne D, de Jonge H, Melnyk O, Vicogne J.
Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.
Chem Sci. 2015, 6, 2110-21

Boll E, Drobecq H, Ollivier N, Blanpain A, Raibaut L, Desmet R, Vicogne J, Melnyk O. One-pot chemical synthesis of small ubiquitin-like modifier protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates.
Nat Protocol. 2015 Feb;10(2):269-92.

Patents:
J. Vicogne, O Melnyk, B Leclercq, E Adriaenssens, N Ollivier, E Gherardi
« Multimeric compounds of a kringle domain from the hepatocyte growth factor / scatter factor (HGF/SF) »
by: Université des Sciences et Technologies de Lille – Lille 1, CNRS, Institut Pasteur de Lille, Université de Lille 2 Droit et Santé, Universita’ Degli Studi Di Pavia
EP15152 029.3, 21 january 2015
PCT Extension on le 21 january 2016, PCT/EP15152 029.3

J. Vicogne, O Melnyk, B Leclercq, E Adriaenssens, N Ollivier, E Gherardi
« Met receptor agonist proteins »
Déposants : Université des Sciences et Technologies de Lille – Lille 1, CNRS, Institut Pasteur de Lille, Université de Lille 2 Droit et Santé, Universita’ Degli Studi Di Pavia
EP15152027.7, 21 january 2015
PCT Extension on le 21 january 2016, PCT/EP15152027.7